November, 2014

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Improving memory by suppressing a molecule that links aging to Alzheimer’s disease

In a new study conducted by the Sagol Department of Neurobiology at the University of Haifa and published recently in the Journal of Neuroscience, researchers report that they’ve found a way to improve memory by manipulating a specific molecule that is known to function poorly in old age and is closely linked to Alzheimer’s disease.

Getting bigger and biggerThe researchers even succeeded, for the first time, in manipulating the molecule’s operations without creating any cognitive impairment.

“We know that in Alzheimer’s, this protein, known as PERK, doesn’t function properly. Our success in manipulating its expression without causing any harm to the proper functioning of the brain paves the way for improving memory and perhaps even slowing the pathological development of diseases like Alzheimer’s,” said Prof. Kobi Rosenblum, who heads the lab in which the research was done.

Previous studies at the University of Haifa and other labs throughout the world had shown that the brain’s process of formulating memory is linked to the synthesis of proteins; high rates of protein production will lead to a strong memory that is retained over the long term, while a slow rate of protein production leads to weak memories that are less likely to be impressed on a person’s long-term memory and thus forgotten.

In the current study, the researchers, Dr. Hadile Ounallah-Saad and Dr. Vijendra Sharma, both of whom work in Prof. Rosenblum’s lab at the Sagol Department of Neurobiology, sought to examine the activity of a protein called elF2 alpha, a protein that’s known as the “spigot” or regulator that determines the pace of protein synthesis in the brain during memory formation.

From earlier studies the researchers knew that there are three main molecules that act on the protein and either make it work, or stop it from working. During the first stage they sought to determine the relative importance and the task of each one of the molecules that control the activity of efF2 alpha and as a result, the ability to create memories. After doing tests at the tissue and cell levels, the researchers discovered that the main molecule controlling the efF2 alpha’s activity was the PERK molecule.

“The fact that we identified the PERK as the primary controller had particular significance,” said Dr. Ounallah-Saad. “Firstly, of course, we had identified the dominant component. Secondly, from previous studies we already knew that in generative diseases like Alzheimer’s, PERK performs deficiently. Third, PERK acts on various cells, including neurons, as a monitor and controller of metabolic stress. In other words, we found a molecule that has a major impact on the process of creating and formulating memory, and which we know performs deficiently in people with Alzheimer’s disease.”

During the second stage of the study, the researchers sought to examine whether they could manipulate this molecule in rats in a way that would improve memory. To do this they used two accepted methods, one using a drug called a small-molecule inhibitor and the other making a genetic change to the brain cells using a type of virus also used in gene therapy.
After paralyzing PERK’s activity or reducing its expression through gene therapy (which was done with the help of Dr. Efrat Edry, of the University’s Center for Gene Manipulation in the Brain), the researchers measured a 30% increase in the memory of either positive or negative experiences. The rats also demonstrated improved long-term memory and enhanced behavioral plasticity, becoming better able to “forget” a bad experience. In other words, on a behavioral level it was clear that manipulating PERK by either of two methods improved memory and cognitive abilities.

When the researchers examined the tissues on a cell and molecular level, the discovered that the steps they’d taken had indeed stopped the expression of PERK, which allowed the “spigot” — the elF2 alpha protein — to perform better and increase the pace of protein synthesis. Even more, there was a clear correlation between memory function and the degree to which PERK was suppressed; the more efficiently PERK was suppressed, the better the memory function.

But the researchers faced another problem. Previous studies that had manipulated PERK in general in genetically engineered animals led to fixated behavior. “The brain operates in a most sophisticated fashion, with each action closely linked to many other actions,” said Dr. Ounallah-Saad. “In our study we succeeded in maintaining such control of the PERK that it didn’t influence the retrieval of existing memories, or do anything other cognitive damage.”

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Licensed Marriage and Family Therapist from California Joins the ProvenTherapists Team

Janeen Wilson, a qualified and experienced Family Therapist and Counselor has started her online counseling clinic at ProvenTherapy.com. She is available to potential clients for individual and couples therapy through live chat or email service.

JaneenPress Release – 21 Nov. 2014: Janeen Wilson, a licensed Marriage and Family Therapist in the state of California (August 2006) has a Bachelor’s Degree in Psychology and a Master’s degree in Counseling Psychology. Janeen began practicing therapy in 2000 working with a variety of different therapeutic issues and problems. Janeen initially began working with women in Domestic Violence and with adolescent boys struggling with psychiatric issues, bipolar issues and attachment disruption that were in a Residential Treatment setting. Janeen has worked with all ages of children in school based settings and their families addressing issues related to family dynamics, ADHD and emotional disruption. Janeen became very interested in an strength based evidence approach (Multi Dimensional Foster Care) and was formally trained as a Program Director and Family Therapist through this program (MTFC). With this training she focused on assisting families in reuniting youth from foster care back to their homes and strengthening their family systems. She has also worked with families as the Director of the Family Stabilization Team in Boston, MA to prevent youth from being removed from their home, as an Outpatient Therapist and with specialized populations such as the blind. Janeen has worked with a variety of different types of people in different areas, ranging from the tundra in Alaska to urban Boston, rural and urban Pennsylvania as well as in Southern California.

Issues Janeen has worked with ranges from working with the blind community, SED children and their families, Adoption, Foster Care, as well as Addiction and Trauma. Janeen has also been formally trained to work with firefighters to address their specific needs related to work and trauma.

For the last two years Janeen has been working as a Individual and Family therapist in an inpatient dual diagnosis residential setting for individuals struggling with addiction and mental health/trauma issues. Now she has opened her virtual clinic at https://www.proventherapy.com.

Read full press release here…